产品简称

from rabbit, purified by affinity chromatography

NACRES

NA.41

抗体产品类型

primary antibodies

物种反应性

mouse

生物来源

rabbit

单抗克隆号

polyclonal

抗体应用

western blot: suitable

免疫原基因信息

human ... ZEB1(6935)

免疫原蛋白记录号

P37275

外形

Affinity purified

应用

Anti-ZEB1 detects levels of ZEB1 proteins & has been published & validated for use in WB.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

一般描述

Zinc finger E-box-binding homeobox 1 (ZEB1), also known as Transcription factor 8 (TCF8) and Negative regulator of IL2 or NIL-2-A zinc finger protein is a member of the Zinc finger-Homeobox (ZFH)-family of repressors and acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 has also been implicated in regulating the expression of ATP1A1, E-cadherin, BCL6, and RCOR1 genes. ZEB1 regulates neurogenesis and neuronal differentiation, but is also implicated in tumor formation. ZEB1 is expressed in heart and skeletal muscle. Mutations in ZEB1 have been associated with corneal dystrophy.

外形

Affinity purified

免疫原

KLH-conjugated linear peptide corresponding to human ZEB1.

分析说明

Control Mouse embryo e11 tissue lysate

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

质量

Evaluated by Western Blot in mouse embryo e11 tissue lysate.Western Blot Analysis: 1.0 µg/mL of this antibody detected ZEB1 in 10 µg of mouse embryo e11 tissue lysate.

目标描述

~200 kDa observed. The calculated molecular weight is 124 kDa, however ZEB1 has been shown at ~180-210 kDa in western blots (Dave, N., et al. (2011). J. Biol. Chem. 286(14):12024-12032).