| 名称 | JHU37152 |
| 描述 | JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively. |
| 体外活性 | JHU 37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells |
| 体内活性 | JHU 37152 exhibits high in vivo DREADD potency. JHU37152 exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| 溶解度 | DMSO : 72 mg/mL (200.65 mM) Ethanol : 24 mg/mL (66.88 mM) |
| 关键字 | inhibit | hM3Dq | Clozapine | Inhibitor | JHU37152 | JHU-37152 | DREADD | Muscarinic acetylcholine receptor | mAChR | hM4Di |
| 相关产品 | Lobelanidine | Posatirelin | Thonzylamine hydrochloride | Sophoflavescenol | Penehyclidine hydrochloride | TAK-071 | Dinotefuran | YM-58790 | Molindone hydrochloride | Clidinium bromide |
| 相关库 | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library |
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